In the past ten years, the City of Chicago has seen a constant increase in meta-human activity. Various groups and organizations have been vying for territory within the city. These factions are as often in conflict with each other as they are with the Chi-Town Champions.
HYDRA: Chicago Cell
- The Grandmaster (Deceased)
- Simile (Deceased)
- Mayor Richard Daley I (Deceased)
AIM: Chicago Cell
- Director Hansel (Deceased)
- Ener-gina
- AIM Superior
- AIM Technician
- AIM Security Operative
- XV-18 Battle Suit
- Atomic Skull
Project Perses
- Agent Orange (Deceased)
- The Keeper (Deceased)
- Doctor Axiom
- Trace
- The Patriot
The Killer Four
The Source
- The Black Staff (Deceased)
- Hellhound I (Deceased)
- Hellhound II (Deceased)
- Hellhound III (Deceased)
- Hellhound IV (Deceased)
- Kafka
- The Hollow
- Inspector Thunder Badger II (Deceased)
- Mayor Richard Daley II (Deceased)
- Solaria II (Deceased)
- Terry Pratchett II (not the author) (Deceased)
The Nameless
- The Unknown
- El Chupacabras
- Nameless Thrall
Independents
- Master Wu (Deceased)